Nanocarriers in Tuberculosis Treatment: Challenges and Delivery Strategies
نویسندگان
چکیده
The World Health Organization identifies tuberculosis (TB), caused by Mycobacterium tuberculosis, as a leading infectious killer. Although conventional treatments for TB exist, they come with challenges such heavy pill regimen, prolonged treatment duration, and strict schedule, to multidrug-resistant (MDR) extensively drug-resistant (XDR) strains. rise of MDR strains endangers future control. Despite these concerns, the hunt an efficient continues. One breakthrough has been use nanotechnology in medicines, presenting novel approach treatment. Nanocarriers, lipid nanoparticles, nanosuspensions, liposomes, polymeric micelles, facilitate targeted delivery anti-TB drugs. benefits nanocarriers include reduced drug doses, fewer side effects, improved solubility, better bioavailability, patient compliance, speeding up recovery. Additionally, can be made even more linking them ligands mannose or hyaluronic acid. This review explores innovative treatments, including studies on containing drugs related patents.
منابع مشابه
Exosomes as nanocarriers for siRNA delivery: paradigms and challenges
Exosomes are nano-sized vesicles that facilitate intercellular communications through carrying genetic materials and functional biomolecules. Owing to their unique size and structure, exosomes have emerged as a useful tool to overcome the limitations of siRNA delivery. The use of exosomes as siRNA delivery vehicles lacks certain disadvantages of the existing foreign delivery systems such as vir...
متن کاملgluten tolerance; potential challenges in treatment strategies
tolerable gluten thresholds in gluten free products have long been debated together with issues of cross contamination of gluten free cereals during the milling process. it is well established that a totally gluten free diet is virtually impossible owing to the presence of traces of gluten. it is estimated that daily consumption of gluten from contaminated gluten free foods is in the range of 5...
متن کاملNanocarriers for Nitric Oxide Delivery
Nitric oxide (NO) is a promising pharmaceutical agent that has vasodilative, antibacterial, and tumoricidal effects. To study the complex and wide-ranging roles of NO and to facilitate its therapeutic use, a great number of synthetic compounds (e.g., nitrosothiols, nitrosohydroxyamines, N-diazeniumdiolates, and nitrosyl metal complexes) have been developed to chemically stabilize and release NO...
متن کاملNanocarriers in modern drug delivery systems
Introduction Nanotechnology consists in manufacturing nanometre-sized materials and structures, i.e. up to 100 nm. There is no doubt that it is one of the most dynamically developing branches of science and technology. This is a multidisciplinary branch, as it combines the elements of solid-state physics, chemistry, material science and molecular biology that interpenetrate each other. Nanotech...
متن کاملChallenges in design of translational nanocarriers.
Cancer drug delivery achieving high therapeutic efficacy and low side effects requires a nanocarrier to tightly retain the drug, efficiently reach the tumor, then quickly enter the tumor cells and release the drug. Furthermore, the nanocarrier intended for clinical applications should use materials safe as pharmaceutical excipients and its formulation (nanomedicine) should have good manufacture...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pharmaceuticals
سال: 2023
ISSN: ['1424-8247']
DOI: https://doi.org/10.3390/ph16101360